Browsing by Author "Gerwick, William H."
Now showing items 1-12 of 12
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Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darie´n
Tayler, Nicole M.; Boya, Cristopher A.; Herrera, Liuris; Moy, Jamie; Ng, Michelle; Pineda, Laura; Almanza, Alejandro; Rosero, Sara; Coronado, Lorena M.; Correa, Ricardo; Santamarıá, Ricardo; Caballero, Zuleima; Durant-Archibold, Armando A.; Tidgewell, Kevin J.; Balunas, Marcy J.; Gerwick, William H.; Spadafora, Alida; Gutiérrez, Marcelino; Spadafora, Carmenza (2019-04-02)Cocos nucifera (C. nucifera) (the coconut palm tree) has been traditionally used to fight a number of human diseases, but only a few studies have tested its components against parasites such as those that cause malaria. ... -
Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién
Tayler, Nicole M.; Boya, Cristopher A.; Herrera, Liuris; Moy, Jamie; Ng, Michelle; Pineda, Laura; Almanza, Alejandro; Rosero, Sara; Coronado, Lorena M.; Correa, Ricardo; Santamaría, Ricardo; Caballero, Zuleima; Durant-Archibold, Armando A.; Tidgewell, Kevin J.; Balunas, Marcy J.; Gerwick, William H.; Spadafora, Alida; Gutiérrez, Marcelino; Spadafora, Carmenza (2019-04-02)Cocos nucifera (C. nucifera) (the coconut palm tree) has been traditionally used to fight a number of human diseases, but only a few studies have tested its components against parasites such as those that cause malaria. ... -
Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group
Shao, Chang-Lun; Feng Mou, Xiao; Cao, Fei; Spadafora, Carmenza; Glukhov, Evgenia; Gerwick, Lena; Yun Wang, Chang; Gerwick, William H. (2018-01-12)We reported previously the discovery of the potent antimalarial 40-membered macrolide bastimolide A (1) from the tropical marine cyanobacterium Okeania hirsute. Continued investigation has led to the discovery of a new ... -
Coibacins A D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins
Balunas, Marcy J.; Grosso, Manuel F.; Villa, Francisco A.; Engene, Niclas; McPhail, Kerry L.; Tidgewell, Kevin; Pineda, Laura M.; Gerwick, Lena; Spadafora, Carmenza; Kyle, Dennis E.; Gerwick, William H. (2012-08-03)Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, ... -
Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp. nov.
Malloy, Karla L.; Suyama, Takashi L.; Engene, Niclas; Debonsi, Hosana; Cao, Zhengyu; Matainaho, Teatulohi; Spadafora, Carmenza; Murray, Thomas F.; Gerwick, William H. (2012-01-27)Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing ... -
Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp. nov.
Malloy, Karla L.; Suyama, Takashi L.; Engene, Niclas; Debonsi, Hosana; Cao, Zhengyu; Matainaho, Teatulohi; Spadafora, Carmenza; Murray, Thomas F.; Gerwick, William H. (2011-12-12)Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing ... -
Cytotoxic Veraguamides, Alkynyl Bromide-containing cyclic Depsipeptides from the marine Cyanobacterium cf. Osciallatoria margaritifera. EmilyCytotoxic Veraguamides, Alkynyl Bromide-containing cyclic Depsipeptides from the marine Cyanobacterium cf. Osciallatoria margaritifera.
Mevers, Emily; Liu, Wei-Ting; Engene, Niclas; Mohimani, Hosein; Byrum, Tara; Pevzner, Pavel A.; Dorrestein, Pieter C.; Spadafora, Carmenza; Gerwick, William H. (2011-04-13)A family of cancer cell cytotoxic cyclodepsipeptides, veraguamides A-C( 1-3) and H-L( 4-8), were isolated from a collection of cf. Oscillatoria margaritifera obtained from the Coiba National Park, Panama, as part of the ... -
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species
Naman, C. Benjamin; Almaliti, Jehad; Armstrong, Lorene; Caro-Díaz, Eduardo J.; Pierce, Marsha L.; Glukhov, Evgenia; Fenner, Amanda; Spadafora, Carmenza; Debonsi, Hosana M.; Dorrestein, Pieter C.; Murray, Thomas F.; Gerwick, William H. (2017-08-07)A recent untargeted metabolomics investigation into the chemical profile of 10 organic extracts from cf. Symploca spp. revealed several interesting chemical leads for further natural product drug discovery. Subsequent ... -
Dudawalamides A−D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens
Almaliti, Jehad; Malloy, Karla L.; Glukhov, Evgenia; Spadafora, Carmenza; Gutierrez, Marcelino; Gerwick, William H. (2017-05-23)HPLC. DudA family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A−D (1−4), was isolated from a Papua New Guinean field collection of the cyanobacterium Moorea producens ... -
Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β‑Amino Acids
Fenner, Amanda M.; Engene, Niclas; Spadafora, Carmenza; Gerwick, William H.; Balunas, Marcy J. (2016-01-19)From a collection of marine cyanobacteria made in the Coiba National Park along the Pacific coast of the Republic of Panama a novel cyclic depsipeptide, given the trivial name medusamide A, has been isolated and fully ... -
Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi
Martínez, Sergio Luis; Cherigo, Lilia; Higginbotham, Sarah; Arnold, Elizabeth; Spadafora, Carmenza; Ibañez, Alicia; Gerwick, William H.; Cubilla-Rios, Luis (2011-06-14)Parasitic infections are major causes of human chronic diseases in most countries of the tropics. The parasites include protozoa and helminths, infect billions of people, and the resulting diseases cause debilitating ... -
Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi
Martínez-Luis, Sergio; Cherigo, Lilia; Higginbotham, Sarah; Arnold, Elizabeth; Spadafora, Carmenza; Ibañez, Alicia; Gerwick, William H.; Cubilla-Rios, Luis (2011-03-30)Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate endophytic fungi from different regions of Panama and then to test their potential therapeutic ...