Browsing by Author "Lleonart, Ricardo"
Now showing items 1-9 of 9
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AFLP Polymorphisms Allow High Resolution Genetic Analysis of American Tegumentary Leishmaniasis Agents Circulating in Panama and Other Members of the Leishmania Genus
Restrepo, Carlos M.; De La Guardia, Carolina; Sousa, Octavio E.; Fernández, Patricia L.; Calzada, José E.; Lleonart, Ricardo (2013-09-09)American Tegumentary Leishmaniasis is caused by parasites of the genus Leishmania, and causes significant health problems throughout the Americas. In Panama, Leishmania parasites are endemic, causing thousands of new cases ... -
Amplified fragment length polymorphisms reveals high intraspecific variability in field isolates of Leishmania panamensis
Restrepo, Carlos M.; Pérez Lao, Efraín; De La Guardia, Carolina; Sousa, Octavio E.; Calzada, José E.; Lleonart, Ricardo (2011-04-01)Leishmania parasites cause leishmaniasis, a potentially deadly re-emergent disease that affects millions throughout the world. In Panama, the disease is showing an increasing trend, with estimates of thousands of new cases ... -
Betacoronavirus genomes: How genomic information has been used to deal with past outbreaks and the COVID-19 pandemic
Llanes, Alejandro; Restrepo, Carlos M.; Caballero, Zuleima; Rajeev, Sreekumari; Kennedy, Melissa A.; Lleonart, Ricardo (2020-05-27)In the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic information has been widely used to understand the pathogenesis, animal origin ... -
Environmental Conditions May Shape the Patterns of Genomic Variations in Leishmania panamensis
Restrepo, Carlos M.; Llanes, Alejandro; Cedeño, Eymi M.; Chang, Jim H.; Álvarez, Jennifer; Ríos, Margarita; Penagos, Homero; Suárez, José A.; Lleonart, Ricardo (2019-10-24)Due to the absence of transcriptional regulation of gene expression in Leishmania parasites, it is now well accepted that several forms of genomic variations modulate the levels of critical proteins through changes in gene ... -
Environmental Conditions May Shape the Patterns of Genomic Variations in Leishmania panamensis
Restrepo, Carlos M.; Llanes, Alejandro; Cedeño, Eymi M.; Chang, Jim H.; Álvarez, Jennifer; Ríos, Margarita; Penagos, Homero; Suárez, José A.; Lleonart, Ricardo (2019-10-24)Due to the absence of transcriptional regulation of gene expression in Leishmania parasites, it is now well accepted that several forms of genomic variations modulate the levels of critical proteins through changes in gene ... -
The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.
Llanes, Alejandro; Restrepo, Carlos Mario; Del Vecchio, Gina; Anguizola, Franklin Jose´; Lleonart, Ricardo (2015-02-24)Kinetoplastid parasites of the Leishmania genus cause several forms of leishmaniasis. Leishmania species pathogenic to human are separated into two subgenera, Leishmania (Leishmania) and L. (Viannia). Species from the ... -
Genome-wide discovery and development of polymorphic microsatellites from Leishmania panamensis parasites circulating in central Panama
Restrepo, Carlos M.; Llanes, Alejandro; De La Guardia, Carolina; Lleonart, Ricardo (2015-10-12)The parasite Leishmania panamensis is the main cause of leishmaniasis in Panama. The disease is largely uncontrolled, with a rising incidence and no appropriate control measures. While microsatellites are considered some ... -
A Pseudopterane Diterpene Isolated From the Octocoral Pseudopterogorgia acerosa Inhibits the Inflammatory Response Mediated by TLR-Ligands and TNF-Alpha in Macrophages
González, Yisett; Doens, Deborah; Santamaría, Ricardo; Ramos, Marla; Restrepo, Carlos M.; Barros de Arruda, Luciana; Lleonart, Ricardo; Gutiérrez, Marcelino; Fernández, Patricia L. (2013-12-16)Several diterpenoids isolated from terrestrial and marine environments have been identified as important anti-inflammatory agents. Although considerable progress has been made in the area of anti-inflammatory treatment, ... -
VianniaTopes: a database of predicted immunogenic peptides for Leishmania (Viannia) species
Llanes, Alejandro; Restrepo, Carlos Mario; Lleonart, Ricardo (2018-09-21)Leishmania is a protozoan parasite causing several disease presentations collectively known as leishmaniasis. Pathogenic species of Leishmania are divided into two subgenera, L. (Leishmania) and L. (Viannia). Species ...