Listar por autor "Llanes, Alejandro"
Mostrando ítems 1-12 de 12
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Betacoronavirus genomes: How genomic information has been used to deal with past outbreaks and the COVID-19 pandemic
Llanes, Alejandro; Restrepo, Carlos M.; Caballero, Zuleima; Rajeev, Sreekumari; Kennedy, Melissa A.; Lleonart, Ricardo (2020-05-27)In the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic information has been widely used to understand the pathogenesis, animal origin ... -
Complete Genome Sequence of a Virulent Leptospira interrogans Serovar Copenhageni Strain, Assembled with a Combination of Nanopore and Illumina Reads
Llanes, Alejandro; Prakoso, Dhani; Restrepo, Carlos Mario; Rajeev, Sreekumari (2020-04-23)Here, we present the complete genome sequence of a highly virulent Leptospira interrogans serovar Copenhageni strain isolated from a dog with severe leptospirosis. In this work, a gapless genome draft was assembled with a ... -
Detection and Characterization of Leptospira Infection and Exposure in Rats on the Caribbean Island of Saint Kitts
Rajeev, Sreekumari; Shiokawa, Kanae; Llanes, Alejandro; Rajeev, Malavika; Restrepo, Carlos Mario; Chin, Raymond; Cedeño, Eymi; Ellis, Esteban (2020-02-22)In this study, we detected and characterized Leptospira infection and exposure in rats on the Caribbean island of Saint Kitts for the first time. We detected Leptospira infection in 17/29 (59%), 14/29 (48) %, and 11/29 (38) ... -
Environmental Conditions May Shape the Patterns of Genomic Variations in Leishmania panamensis
Restrepo, Carlos M.; Llanes, Alejandro; Cedeño, Eymi M.; Chang, Jim H.; Álvarez, Jennifer; Ríos, Margarita; Penagos, Homero; Suárez, José A.; Lleonart, Ricardo (2019-10-24)Due to the absence of transcriptional regulation of gene expression in Leishmania parasites, it is now well accepted that several forms of genomic variations modulate the levels of critical proteins through changes in gene ... -
Environmental Conditions May Shape the Patterns of Genomic Variations in Leishmania panamensis
Restrepo, Carlos M.; Llanes, Alejandro; Cedeño, Eymi M.; Chang, Jim H.; Álvarez, Jennifer; Ríos, Margarita; Penagos, Homero; Suárez, José A.; Lleonart, Ricardo (2019-10-24)Due to the absence of transcriptional regulation of gene expression in Leishmania parasites, it is now well accepted that several forms of genomic variations modulate the levels of critical proteins through changes in gene ... -
First Whole Genome Sequence of Anaplasma platys, an Obligate Intracellula Rickettsial Pathogen of Dogs
Llanes, Alejandro; Rajeev, Sreekumari (2020-04-10)We have assembled the first genome draft of Anaplasma platys, an obligate intracellular rickettsia, and the only known bacterial pathogen infecting canine platelets. A. platys is a not-yet-cultivated bacterium that causes ... -
The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.
Llanes, Alejandro; Restrepo, Carlos Mario; Del Vecchio, Gina; Anguizola, Franklin Jose´; Lleonart, Ricardo (2015-02-24)Kinetoplastid parasites of the Leishmania genus cause several forms of leishmaniasis. Leishmania species pathogenic to human are separated into two subgenera, Leishmania (Leishmania) and L. (Viannia). Species from the ... -
Genome-wide discovery and development of polymorphic microsatellites from Leishmania panamensis parasites circulating in central Panama
Restrepo, Carlos M.; Llanes, Alejandro; De La Guardia, Carolina; Lleonart, Ricardo (2015-10-12)The parasite Leishmania panamensis is the main cause of leishmaniasis in Panama. The disease is largely uncontrolled, with a rising incidence and no appropriate control measures. While microsatellites are considered some ... -
Genomic Variability among Field Isolates and Laboratory-Adapted Strains of Leptospira borgpetersenii Serovar Hardjo
Llanes, Alejandro; Restrepo, Carlos Mario; Ferreiro, Pablo Riesgo; Rajeev, Sreekumari (2018-05-22)Leptospira borgpetersenii serovar Hardjo colonizes cattle kidneys and may occasionally infect humans and other mammals. Strains belonging to two clonal subtypes (types A and B) with marked differences in their pathogenicity ... -
A Marine Diterpenoid Modulates the Proteasome Activity in Murine Macrophages Stimulated with LPS
González, Yisett; Doens, Deborah; Cruz, Héctor; Santamaría, Ricardo; Gutiérrez, Marcelino; Llanes, Alejandro; Fernández, Patricia L. (2018-10-05)he proteasome is an intracellular complex that degrades damaged or unfolded proteins and participates in the regulation of several processes. The immunoproteasome is a specialized form that is expressed in response to ... -
VianniaTopes: a database of predicted immunogenic peptides for Leishmania (Viannia) species
Llanes, Alejandro; Restrepo, Carlos Mario; Lleonart, Ricardo (2018-09-21)Leishmania is a protozoan parasite causing several disease presentations collectively known as leishmaniasis. Pathogenic species of Leishmania are divided into two subgenera, L. (Leishmania) and L. (Viannia). Species ... -
Whole Genome Sequencing Allows Better Understanding of the Evolutionary Historyof Leptospira interrogans Serovar Hardjo
Llanes, Alejandro; Restrepo, Carlos Mario; Rajeev, Sreekumari (2016-07-21)The genome of a laboratory-adapted strain of Leptospira interrogans serovar Hardjo was sequenced and analyzed. Comparison of the sequenced genome with that recently published for a field isolate of the same serovar revealed ...