Listar por autor "Rao, KS Jagannatha"
Mostrando ítems 1-20 de 25
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Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery
Lakey-Beitia, Johant; Doens, Deborah; Kumar, D Jagadeesh; Murillo, Enrique; L Fernandez, Patricia; Rao, KS Jagannatha; Durant-Archibold, Armando A (2017-05-15)Alzheimer’s disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for ... -
Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-β Aggregation in Alzheimer's Disease
Lakey-Beitia, Johant; González, Yisett; Doens, Deborah; Stephens, David E; Santamaría, Ricardo; Murillo, Enrique; Gutiérrez, Marcelino; L Fernández, Patricia; Rao, KS Jagannatha; Larionov, Oleg V; Durant-Archibold, Armando A (2017-01-01)Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting the elderly population worldwide. Brain inflammation plays a key role in the progression of AD. Deposition of senile plaques in the brain ... -
Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis
Lakey-Beitia, Johant; Kumar D., Jagadeesh; Hegde, Muralidhar L; Rao, KS Jagannatha (2019-11-07)Alzheimer’s disease (AD) is the most devastating neurodegenerative disorder that affects the aging population worldwide. Endogenous and exogenous factors are involved in triggering this complex and multifactorial disease, ... -
Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson's Disease
Vasquez, Velmarini; Mitra, Joy; Hegde, Pavana M; Pandey, Arvind; Sengupta, Shiladitya; Mitra, Sankar; Rao, KS Jagannatha; Hegde, Muralidhar L (2019-09-01)Alpha-synuclein (α-Syn) overexpression and misfolding/aggregation in degenerating dopaminergic neurons have long been implicated in Parkinson’s disease (PD). The neurotoxicity of α-Syn is enhanced by iron (Fe) and other ... -
Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson’s disease
Vasquez, Velmarini; Mitra, Joy; Hegde, Pavana M; Pandey, Arvind; Sengupta, Shiladitya; Mitra, Sankar; Rao, KS Jagannatha; Hegde, Muralidhar L (2017-01-01)Alpha-synuclein (α-Syn) overexpression and misfolding/aggregation in degenerating dopaminergic neurons have long been implicated in Parkinson’s disease (PD). The neurotoxicity of α-Syn is enhanced by iron (Fe) and other ... -
Comparative study on anti-oxidant and anti-inflammatory activities of Caesalpinia crista and Centella asiatica leaf extracts
Ramesh, BN; Girish, TK; Raghavendra, RH; Akhilender Naidu, K; Rao, UJS Prasada; Rao, KS Jagannatha (2014-04-01)Background: Amyloidosis, oxidative stress and inflammation have been strongly implicated in neurodegenerative disorders like Alzheimer's disease. Traditionally, Caesalpinia crista and Centella asiatica leaf extracts are ... -
Copper interactions with DNA of chromatin and its rolein neurodegenerative disorders.
Govindaraju, M; Shekar, HS; Sateesha, SB; Vasudeva Raju, P; Rao, KR Sambasiva; Rao, KS Jagannatha; Rajamma, AJ (2013-10-01)In this study, we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism, in combination with UV-absorbance and fluorescence spectroscopy. Results confirm ... -
Development of Aluminium Based Surface Nano Composites Using Friction Stir Processing
Rahul, Rahul; Rajulapati, K. V.; Reddy, G. M.; Rao, KS Jagannatha (2018-02-22)Friction Stir Processing is a relatively new technique which has been developed for microstructural modification of metallic materials through intense, localized plastic deformation. The current research work deals with ... -
Development of anthracycline-induced dilated cardiomyopathy due to mutation on LMNA gene in a breast cancer patient: a case report
Chichaco Kuruc, Jock; Durant-Archibold, Armando A.; Motta, Jorge; Rao, KS Jagannatha; Trachtenberg, Barry; Ramos, Carlos; Wang, Hongyu; Gorenstein, David; Vannberg, Fredrik; Jordan, King (2019-07-16)Background Anthracyclines are highly effective anticancer medication prescribed for the treatment of breast cancer. Nevertheless, the use of anthracyclines as chemotherapeutic agents involves a risk for development of ... -
Development of anthracycline-induced dilated cardiomyopathy due to mutation on LMNA gene in a breast cancer patient: a case report
Durant-Archibold, Armando A; Chichaco Kuruc, Jock; Motta, Jorge; Rao, KS Jagannatha; Trachtenberg, Barry; Ramos, Carlos; Wang, Hongyu; Gorenstein, David; Vannberg, Fredrik; Jordan, King (2019-07-16)Background Anthracyclines are highly effective anticancer medication prescribed for the treatment of breast cancer. Nevertheless, the use of anthracyclines as chemotherapeutic agents involves a risk for development of ... -
Effect of Post Weld Heat Treatments on the Elevated Temperature Mechanical Properties of Ti6Al4V Friction Welds
Rahul, Rahul; Rajulapati, KV; Reddy, GM; Mohandas, T; Rao, KS Jagannatha (2018-02-09)The {\alpha}+\b {eta} titanium alloy (Ti6Al4V) has been successfully joined using rotary friction welding. To investigate the influence of post weld heat treatments on the microstructure and mechanical properties of the ... -
The effects of impaired cerebral circulation on Alzheimer's disease pathology: evidence from animal studies.
Villarreal, Alcibiades E.; Barron, Rachel; Rao, KS Jagannatha; Britton, Gabrielle B. (2014-01-01)Persistent systemic hypoxia, a direct consequence of alterations in vascular function, can compromise the brain by increasing the risk of developing dementias such as Alzheimer’s disease (AD). Vascular contributions to ... -
In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics.
Berrocal, Ruben; Vasudevaraju, Padmaraju; Indi, Shantinath Satappa; Rao, Krothapalli Raja Surya Sambasiva; Rao, KS Jagannatha (2014-01-01)α-Synuclein aggregation is one of the major etiological factors implicated in Parkinson's disease (PD). The prevention of ggregation of α-synuclein is a potential therapeutic intervention for preventing PD. The discovery ... -
An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson’s Disease
Vasquez, Velmarini; Mitra, Joy; Perry, George; Rao, KS Jagannatha; Hegde, Muralidhar L. (2018-11-08)Altered expression of α-synuclein is linked to Parkinson’s disease (PD). A major challenge to explore how the increased α-synuclein affect neurotoxicity is the lack of a suitable human neuronal cell model that mimics this ... -
The lipid content and fatty acid composition of four eastern central Pacific native fish species
Murillo, Enrique; Rao, KS Jagannatha; Durant-Archibold, Armando A. (2014-02-01)Fish is an important source of nutritious n-3 fatty acids, which are necessary for the prevention of cardiovascular and neurological diseases. The lipid content and fatty acid composition of economically important fishes ... -
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Mitra, Joy; Guerrero, Erika N; Hegde, Pavana M; Liachko, Nicole F; Wang, Haibo; Vasquez, Velmarini; Gao, Junling; Pandey, Arvind; Taylor, J Paul; Kraemer, Brian C; Wu, Ping; Boldogh, Istvan; Garruto, Ralph M; Mitra, Sankar; Rao, KS Jagannatha; Hegde, Muralidhar L (2019-03-05)Genome damage and their defective repair have been etiologically linked to degenerating neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the specific mechanisms remain enigmatic. The ... -
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challenges
Vasquez, Velmarini; Mitra, Joy; Wang, Haibo; Hegde, Pavana M; Rao, KS Jagannatha; Hegde, Muralidhar L (2020-02-01)α-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies (LBs) present in dopaminergic neurons affected by Parkinson’s disease (PD). Despite an enormous increase in emerging knowledge, the mechanism(s) ... -
New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases
Mitra, Joy; Guerrero, Erika N; Hegde, Pavana M; Wang, Haibo; Boldogh, Istvan; Rao, KS Jagannatha; Mitra, Sankar; Hegde, Muralidhar L (2014-07-17)The primary cause (s) of neuronal death in most cases of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are still unknown. However, the association of certain etiological factors, eg, oxidative ... -
Panamanian Start-ups that Propel Research and Higher Learning
Psychoyos, Debbie; Rao, KS Jagannatha; Archer Svenson, Nanette; Bernett, Gladys; de Gracia, Guillermina; De Leon, Nadia (2018-10-22)The Republic of Panama can boast of a steadily rising GDP with among the highest economic growth rates in the region, an expanding international services sector, robust financial and banking systems, and relative political ... -
Production of pullulan using jaggery as substrate by Aureobasidium pullulans MTCC 2195
Ganduri, VS; Rao, KS Jagannatha; Mangamuri, Usha Kiranmayi; Lakahmi, Vijaya M; Poda, Sudhakar (2016-04-01)Shake-flask fermentation, under batch cultivation, was investigated for the production of fungal exopolysaccharide, pullulan using jaggery (a traditional concentrated sugar cane juice) as a carbon substrate by Aureobasidium ...