Listar por autor "Restrepo, Carlos M."
Mostrando ítems 1-9 de 9
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AFLP Polymorphisms Allow High Resolution Genetic Analysis of American Tegumentary Leishmaniasis Agents Circulating in Panama and Other Members of the Leishmania Genus
Restrepo, Carlos M.; De La Guardia, Carolina; Sousa, Octavio E.; Fernández, Patricia L.; Calzada, José E.; Lleonart, Ricardo (2013-09-09)American Tegumentary Leishmaniasis is caused by parasites of the genus Leishmania, and causes significant health problems throughout the Americas. In Panama, Leishmania parasites are endemic, causing thousands of new cases ... -
Amplified fragment length polymorphisms reveals high intraspecific variability in field isolates of Leishmania panamensis
Restrepo, Carlos M.; Pérez Lao, Efraín; De La Guardia, Carolina; Sousa, Octavio E.; Calzada, José E.; Lleonart, Ricardo (2011-04-01)Leishmania parasites cause leishmaniasis, a potentially deadly re-emergent disease that affects millions throughout the world. In Panama, the disease is showing an increasing trend, with estimates of thousands of new cases ... -
Betacoronavirus genomes: How genomic information has been used to deal with past outbreaks and the COVID-19 pandemic
Llanes, Alejandro; Restrepo, Carlos M.; Caballero, Zuleima; Rajeev, Sreekumari; Kennedy, Melissa A.; Lleonart, Ricardo (2020-05-27)In the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic information has been widely used to understand the pathogenesis, animal origin ... -
DNA Repair Mechanisms as Drug Targets in Prokaryotes
Coronado, Lorena M.; De La Guardia, Carolina I.; González, Yisett S.; Restrepo, Carlos M.; Tayler, Nicole M. (2011-07-01)Nowadays, a great amount of pathogenic bacteria has been identified such as Mycobacterium sp. and Helicobacter pylori and have become a serious health problem around the world. These bacteria have developed several DNA ... -
Environmental Conditions May Shape the Patterns of Genomic Variations in Leishmania panamensis
Restrepo, Carlos M.; Llanes, Alejandro; Cedeño, Eymi M.; Chang, Jim H.; Álvarez, Jennifer; Ríos, Margarita; Penagos, Homero; Suárez, José A.; Lleonart, Ricardo (2019-10-24)Due to the absence of transcriptional regulation of gene expression in Leishmania parasites, it is now well accepted that several forms of genomic variations modulate the levels of critical proteins through changes in gene ... -
Environmental Conditions May Shape the Patterns of Genomic Variations in Leishmania panamensis
Restrepo, Carlos M.; Llanes, Alejandro; Cedeño, Eymi M.; Chang, Jim H.; Álvarez, Jennifer; Ríos, Margarita; Penagos, Homero; Suárez, José A.; Lleonart, Ricardo (2019-10-24)Due to the absence of transcriptional regulation of gene expression in Leishmania parasites, it is now well accepted that several forms of genomic variations modulate the levels of critical proteins through changes in gene ... -
Frequency of Toxoplasma gondii and Risk Factors Associated with the Infection in Stray Dogs and Cats of Panama
Fábrega, Lorena; Restrepo, Carlos M.; Torres, Alicia; Smith, Diorene; Chan, Patricia; Pérez, Dimas; Cumbrera, Alberto; Caballero E., Zuleima (2020-06-19)Stray animals such as dogs and cats have an important role in maintaining the transmission cycles and dissemination of Toxoplasma gondii. Therefore, the objective of this study was to evaluate the frequency of T. gondii ... -
Genome-wide discovery and development of polymorphic microsatellites from Leishmania panamensis parasites circulating in central Panama
Restrepo, Carlos M.; Llanes, Alejandro; De La Guardia, Carolina; Lleonart, Ricardo (2015-10-12)The parasite Leishmania panamensis is the main cause of leishmaniasis in Panama. The disease is largely uncontrolled, with a rising incidence and no appropriate control measures. While microsatellites are considered some ... -
A Pseudopterane Diterpene Isolated From the Octocoral Pseudopterogorgia acerosa Inhibits the Inflammatory Response Mediated by TLR-Ligands and TNF-Alpha in Macrophages
González, Yisett; Doens, Deborah; Santamaría, Ricardo; Ramos, Marla; Restrepo, Carlos M.; Barros de Arruda, Luciana; Lleonart, Ricardo; Gutiérrez, Marcelino; Fernández, Patricia L. (2013-12-16)Several diterpenoids isolated from terrestrial and marine environments have been identified as important anti-inflammatory agents. Although considerable progress has been made in the area of anti-inflammatory treatment, ...