Browsing by Author "Schwartz, Zvi"
Now showing items 1-11 of 11
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Differential responses of osteoblast lineage cells to nanotopographically-modified, microroughened titaniumealuminumevanadium alloy surfaces
Gittens, Rolando A.; Olivares-Navarrete, Rene; McLachlan, Taylor; Cai, Ye; Hyzy, Sharon L.; Schneider, Jennifer M.; Schwartz, Zvi; Sandhage, Kenneth H.; Boyan, Barbara D. (2012-09-16)Surface structural modifications at the micrometer and nanometer scales have driven improved success rates of dental and orthopaedic implants by mimicking the hierarchical structure of bone. However, how initial ... -
The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation
Gittens, Rolando A.; McLachlan, Taylor; Olivares-Navarrete, Rene; Cai, Ye; Berner, Simon; Tannenbaum, Rina; Schwartz, Zvi; Sandhage, Kenneth H.; Boyan, Barbara D. (2011-02-08)Titanium (Ti) osseointegration is critical for the success of dental and orthopedic implants. Previous studies have shown that surface roughness at the micro- and submicro-scales promotes osseointegration by enhancing ... -
Effects of structural properties of electrospun TiO2 nanofiber meshes on their osteogenic potential
Wang, Xiaokun; Gittens, Rolando A.; Song, Rosemary; Tannenbaum, Rina; Olivares-Navarrete, Rene; Schwartz, Zvi; Chen, Haifeng; Boyan, Barbara D. (2011-10-31)Ideal outcomes in the field of tissue engineering and regenerative medicine involve biomaterials that can enhance cell differentiation and production of local factors for natural tissue regeneration without the use of ... -
Electrical Polarization of Titanium Surfacesfor the Enhancement of Osteoblast Differentiation
Gittens, Rolando A.; Olivares-Navarrete, Rene; Rettew, Robert; Butera, Robert J.; Alamgir, Faisal M.; Boyan, Barbara D.; Schwartz, Zvi (2013-08-29)Electrical stimulation has been used clinically to promote bone regeneration in cases of fractures with delayed union or nonunion, with several in vitro and in vivo reports suggesting its beneficial effects on bone formation. ... -
Implant osseointegration and the role of microroughness and nanostructures: Lessons for spine implants
Gittens, Rolando A.; Olivares-Navarrete, Rene; Schwartz, Zvi; Boyan, Barbara D. (2014-04-08)The use of spinal implants for spine fusion has been steadily increasing to avoid the risks of complications and donor site morbidity involved when using autologous bone. A variety of fusion cages are clinically available, ... -
Osteoblasts exhibit a more differentiated phenotype and increased bone morphogenetic protein production on titanium alloy substrates than on poly-ether-ether-ketone
Olivares-Navarrete, Rene; PhD, DDS; Gittens, Rolando A.; MS; Schneider, Jennifer M.; MS; Hyzy, Sharon L.; BS; Haithcock, David A.; Ullrich, Peter F. MD; Schwartz, Zvi; Boyan, Barbara D. (2012-01-12)Multiple biomaterials are clinically available to spine surgeons for performing interbody fusion. Poly-ether-ether-ketone (PEEK) is used frequently for lumbar spine interbody fusion, but alternative materials are also used, ... -
Regulating in vivo calcification of alginate microbeads
S.D. Lee, Christopher; Moyer, Hunter R.; Gittens I, Rolando A.; Williams, Joseph K.; Boskey, Adele L.; Boyan, Barbara D.; Schwartz, Zvi (2010-04-02)Alginate calcification has been previously reported clinically and during animal implantation; however no study has investigated the mechanism, extensively characterized the mineral, or evaluated multiple methods to regulate ... -
A review on the wettability of dental implant surfaces I: Theoretical and experimental aspects
Rupp, Frank; Gittens, Rolando A.; Scheideler, Lutz; Marmur, Abraham; Boyan, Barbara D.; Schwartz, Zvi; Geis-Gerstorfer, Jürgen (2014-02-28)The surface wettability of biomaterials determines the biological cascade of events at the biomaterial/ host interface. Wettability is modulated by surface characteristics, such as surface chemistry and surface topography. ... -
A review on the wettability of dental implant surfaces II: Biological and clinical aspects
Gittens, Rolando A.; Scheideler, Lutz; Rupp, Frank; Hyzy, Sharon L.; Geis-Gerstorfer, Jürgen; Schwartz, Zvi; Boyan, Barbara D. (2014-04-05)Dental and orthopedic implants have been under continuous advancement to improve their interactions with bone and ensure a successful outcome for patients. Surface characteristics such as surface topography and surface ... -
Role of a2b1 integrins in mediating cell shape on microtextured titanium surfaces
Lai, Min; Hermann, Christopher D.; Cheng, Alice; Olivares-Navarrete, Rene; Gittens, Rolando A.; Bird, Meredith M.; Walker, Marcus; Cai, Ye; Cai, Kaiyong; Sandhage, Kenneth H.; Schwartz, Zvi; Boyan, Barbara D. (2014-05-07)Surface microroughness plays an important role in determining osteoblast behavior on titanium. Previous studies have shown that osteoblast differentiation on microtextured titanium substrates is dependent on alpha-2 beta-1 ... -
Rough titanium alloys regulate osteoblast production of angiogenic factors
Olivares-Navarrete, Rene; DDS; PhD; Hyzy, Sharon L.; MS; Gittens, Rolando A.; I, I; Schneider, Jennifer M.; MS; Haithcock, David A.; BS, BS; Ullrich, Peter F.; Slosar, Paul J.; MD, MD; Schwartz, Zvi; DMD; PhD; Boyan, Barbara D.; PhD (2013-05-14)Multiple biomaterials are clinically available to spine surgeons for performing interbody fusion. Poly-ether-ether-ketone (PEEK) is used frequently for lumbar spine interbody fusion, but alternative materials are also used, ...