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In vitro and in vivo experimental models for drug screening and development for Chagas disease
(2010-03-02)
Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Although the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control ...
Mycobacterium bovis in Panama, 2013
(2015-06-01)
Panama remains free of zoonotic tuberculosis caused by Mycobacterium bovis. However, DNA fingerprinting of 7 M. bovis isolates from a 2013 bovine tuberculosis outbreak indicated minimal homology with strains previously ...
HS-C reactive protein and red blood cell distribution width as effective markers for hypertension
(International Journal of Advances in Medicine, 2016-04-06)
Background: Hypertension or elevated blood pressure is one of the leading causes of morbidity and mortality. HsCRP, which is a known marker for CVD, is also one of the predictive markers of inflammation processes which ...
Separation of Plasmodium falciparum Late Stage-infected Erythrocytes by Magnetic Means
(2013-02-20)
Unlike other Plasmodium species, P. falciparum can be cultured in the lab, which facilitates its study 1. While the parasitemia achieved can reach the ≈40% limit, the investigator usually keeps the percentage at around ...
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challenges
(2020-02-01)
α-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies (LBs) present in dopaminergic neurons affected by Parkinson’s disease (PD). Despite an enormous increase in emerging knowledge, the mechanism(s) ...
Deterioro cognitivo leve y enfermedad de Alzheimer: Revisión de conceptos
(Investigación y Pensamiento Crítico, 2016-05-01)
La enfermedad de Alzheimer (EA) es una enfermedad neurológica degenerativa que afecta a más de 46 millones de personas alrededor del mundo. Representa el tipo de demencia más común en los adultos mayores y cursa con una ...
New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases
(2014-07-17)
The primary cause(s) of neuronal death in most cases of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are still unknown. However, the association of certain etiological factors, e.g., oxidative ...
A Multicomponent Animal Virus Isolated from Mosquitoes
(2016-09-14)
RNA viruses exhibit a variety of genome organization strategies, including multicomponent genomes in which each segment is packaged separately. Although multicomponent genomes are common among viruses infecting plants and ...
tempo and mode of allopatric divergence in the weakly electric fish Sternopygus dariensis in the Isthmus of Panama
(2019-12-11)
Spatial isolation is one of the main drivers of allopatric speciation, but the extent to which spatiallysegregated populations accumulate genetic differences relevant to speciation is not always clear. We used data from ...
Species Composition and Distribution of Adult Anopheles (Diptera: Culicidae) in Panama
(2008-09-01)
Anopheles (Diptera: Culicidae) species composition and distribution were studied using human landing catch data over a 35-yr period in Panama. Mosquitoes were collected from 77 sites during 228 Þeld trips carried out by ...